Association of infectious mononucleosis with multiple sclerosis. A population-based study.
Identifieur interne : 000742 ( Main/Exploration ); précédent : 000741; suivant : 000743Association of infectious mononucleosis with multiple sclerosis. A population-based study.
Auteurs : Sreeram V. Ramagopalan [Royaume-Uni] ; William Valdar ; David A. Dyment ; Gabriele C. Deluca ; Irene M. Yee ; Gavin Giovannoni ; George C. Ebers ; A Dessa SadovnickSource :
- Neuroepidemiology [ 1423-0208 ] ; 2009.
Descripteurs français
- KwdFr :
- Adulte d'âge moyen, Canada (épidémiologie), Facteurs de risque, Facteurs sexuels, Femelle, Humains, Mononucléose infectieuse (épidémiologie), Mâle, Oreillons (), Oreillons (épidémiologie), Rougeole (), Rougeole (épidémiologie), Rubéole (), Rubéole (épidémiologie), Sclérose en plaques (épidémiologie), Sclérose en plaques (étiologie), Susceptibilité à une maladie, Vaccin antiourlien (administration et posologie), Vaccin antirubéoleux (administration et posologie), Vaccin contre la rougeole (administration et posologie), Vaccin contre la varicelle (administration et posologie), Vaccins anti-hépatite B (administration et posologie), Vaccins antigrippaux (administration et posologie), Varicelle (), Varicelle (épidémiologie), Études cas-témoins, Études de cohortes.
- MESH :
- administration et posologie : Vaccin antiourlien, Vaccin antirubéoleux, Vaccin contre la rougeole, Vaccin contre la varicelle, Vaccins anti-hépatite B, Vaccins antigrippaux.
- épidémiologie : Canada, Mononucléose infectieuse, Oreillons, Rougeole, Rubéole, Sclérose en plaques, Varicelle.
- étiologie : Sclérose en plaques.
- Adulte d'âge moyen, Facteurs de risque, Facteurs sexuels, Femelle, Humains, Mâle, Oreillons, Rougeole, Rubéole, Susceptibilité à une maladie, Varicelle, Études cas-témoins, Études de cohortes.
- Wicri :
- geographic : Canada.
English descriptors
- KwdEn :
- Canada (epidemiology), Case-Control Studies, Chickenpox (epidemiology), Chickenpox (prevention & control), Chickenpox Vaccine (administration & dosage), Cohort Studies, Disease Susceptibility, Female, Hepatitis B Vaccines (administration & dosage), Humans, Infectious Mononucleosis (epidemiology), Influenza Vaccines (administration & dosage), Male, Measles (epidemiology), Measles (prevention & control), Measles Vaccine (administration & dosage), Middle Aged, Multiple Sclerosis (epidemiology), Multiple Sclerosis (etiology), Mumps (epidemiology), Mumps (prevention & control), Mumps Vaccine (administration & dosage), Risk Factors, Rubella (epidemiology), Rubella (prevention & control), Rubella Vaccine (administration & dosage), Sex Factors.
- MESH :
- chemical , administration & dosage : Chickenpox Vaccine, Hepatitis B Vaccines, Influenza Vaccines, Measles Vaccine, Mumps Vaccine, Rubella Vaccine.
- geographic , epidemiology : Canada.
- epidemiology : Chickenpox, Infectious Mononucleosis, Measles, Multiple Sclerosis, Mumps, Rubella.
- etiology : Multiple Sclerosis.
- prevention & control : Chickenpox, Measles, Mumps, Rubella.
- Case-Control Studies, Cohort Studies, Disease Susceptibility, Female, Humans, Male, Middle Aged, Risk Factors, Sex Factors.
Abstract
BACKGROUND
Genetic and environmental factors have important roles in multiple sclerosis (MS) susceptibility. Several studies have attempted to correlate exposure to viral illness with the subsequent development of MS. Here in a population-based Canadian cohort, we investigate the relationship between prior clinical infection or vaccination and the risk of MS.
METHODS
Using the longitudinal Canadian database, 14,362 MS index cases and 7,671 spouse controls were asked about history of measles, mumps, rubella, varicella and infectious mononucleosis as well as details about vaccination with measles, mumps, rubella, hepatitis B and influenza vaccines. Comparisons were made between cases and spouse controls.
RESULTS
Spouse controls and stratification by sex appear to correct for ascertainment bias because with a single exception we found no significant differences between cases and controls for all viral exposures and vaccinations. However, 699 cases and 165 controls reported a history of infectious mononucleosis (p < 0.001, corrected odds ratio 2.06, 95% confidence interval 1.71-2.48). Females were more aware of disease history than males (p < 0.001).
CONCLUSIONS
The data further confirms a reporting distortion between males and females. Historically reported measles, mumps, rubella, varicella and vaccination for hepatitis B, influenza, measles, mumps and rubella are not associated with increased risk of MS later in life. A clinical history of infectious mononucleosis is conspicuously associated with increased MS susceptibility. These findings support studies implicating Epstein-Barr virus in MS disease susceptibility, but a co-association between MS susceptibility and clinically apparent infectious mononucleosis cannot be excluded.
DOI: 10.1159/000201564
PubMed: 19209005
Affiliations:
Links toward previous steps (curation, corpus...)
Le document en format XML
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Ramagopalan</name><affiliation wicri:level="3"><nlm:affiliation>Wellcome Trust Centre for Human Genetics, Oxford, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Wellcome Trust Centre for Human Genetics, Oxford</wicri:regionArea><placeName><settlement type="city">Oxford</settlement><region type="country">Angleterre</region><region type="comté" nuts="2">Oxfordshire</region></placeName></affiliation></author><author><name sortKey="Valdar, William" sort="Valdar, William" uniqKey="Valdar W" first="William" last="Valdar">William Valdar</name></author><author><name sortKey="Dyment, David A" sort="Dyment, David A" uniqKey="Dyment D" first="David A" last="Dyment">David A. Dyment</name></author><author><name sortKey="Deluca, Gabriele C" sort="Deluca, Gabriele C" uniqKey="Deluca G" first="Gabriele C" last="Deluca">Gabriele C. Deluca</name></author><author><name sortKey="Yee, Irene M" sort="Yee, Irene M" uniqKey="Yee I" first="Irene M" last="Yee">Irene M. 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Dyment</name></author><author><name sortKey="Deluca, Gabriele C" sort="Deluca, Gabriele C" uniqKey="Deluca G" first="Gabriele C" last="Deluca">Gabriele C. Deluca</name></author><author><name sortKey="Yee, Irene M" sort="Yee, Irene M" uniqKey="Yee I" first="Irene M" last="Yee">Irene M. Yee</name></author><author><name sortKey="Giovannoni, Gavin" sort="Giovannoni, Gavin" uniqKey="Giovannoni G" first="Gavin" last="Giovannoni">Gavin Giovannoni</name></author><author><name sortKey="Ebers, George C" sort="Ebers, George C" uniqKey="Ebers G" first="George C" last="Ebers">George C. 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xml:lang="fr"><term>Canada</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p><b>BACKGROUND</b></p><p>Genetic and environmental factors have important roles in multiple sclerosis (MS) susceptibility. Several studies have attempted to correlate exposure to viral illness with the subsequent development of MS. Here in a population-based Canadian cohort, we investigate the relationship between prior clinical infection or vaccination and the risk of MS.</p></div><div type="abstract" xml:lang="en"><p><b>METHODS</b></p><p>Using the longitudinal Canadian database, 14,362 MS index cases and 7,671 spouse controls were asked about history of measles, mumps, rubella, varicella and infectious mononucleosis as well as details about vaccination with measles, mumps, rubella, hepatitis B and influenza vaccines. Comparisons were made between cases and spouse controls.</p></div><div type="abstract" xml:lang="en"><p><b>RESULTS</b></p><p>Spouse controls and stratification by sex appear to correct for ascertainment bias because with a single exception we found no significant differences between cases and controls for all viral exposures and vaccinations. However, 699 cases and 165 controls reported a history of infectious mononucleosis (p < 0.001, corrected odds ratio 2.06, 95% confidence interval 1.71-2.48). Females were more aware of disease history than males (p < 0.001).</p></div><div type="abstract" xml:lang="en"><p><b>CONCLUSIONS</b></p><p>The data further confirms a reporting distortion between males and females. Historically reported measles, mumps, rubella, varicella and vaccination for hepatitis B, influenza, measles, mumps and rubella are not associated with increased risk of MS later in life. A clinical history of infectious mononucleosis is conspicuously associated with increased MS susceptibility. These findings support studies implicating Epstein-Barr virus in MS disease susceptibility, but a co-association between MS susceptibility and clinically apparent infectious mononucleosis cannot be excluded.</p></div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">19209005</PMID><DateCompleted><Year>2009</Year><Month>06</Month><Day>30</Day></DateCompleted><DateRevised><Year>2019</Year><Month>10</Month><Day>08</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1423-0208</ISSN><JournalIssue CitedMedium="Internet"><Volume>32</Volume><Issue>4</Issue><PubDate><Year>2009</Year></PubDate></JournalIssue><Title>Neuroepidemiology</Title><ISOAbbreviation>Neuroepidemiology</ISOAbbreviation></Journal><ArticleTitle>Association of infectious mononucleosis with multiple sclerosis. A population-based study.</ArticleTitle><Pagination><MedlinePgn>257-62</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1159/000201564</ELocationID><Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">Genetic and environmental factors have important roles in multiple sclerosis (MS) susceptibility. Several studies have attempted to correlate exposure to viral illness with the subsequent development of MS. Here in a population-based Canadian cohort, we investigate the relationship between prior clinical infection or vaccination and the risk of MS.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">Using the longitudinal Canadian database, 14,362 MS index cases and 7,671 spouse controls were asked about history of measles, mumps, rubella, varicella and infectious mononucleosis as well as details about vaccination with measles, mumps, rubella, hepatitis B and influenza vaccines. Comparisons were made between cases and spouse controls.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">Spouse controls and stratification by sex appear to correct for ascertainment bias because with a single exception we found no significant differences between cases and controls for all viral exposures and vaccinations. However, 699 cases and 165 controls reported a history of infectious mononucleosis (p < 0.001, corrected odds ratio 2.06, 95% confidence interval 1.71-2.48). Females were more aware of disease history than males (p < 0.001).</AbstractText><AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">The data further confirms a reporting distortion between males and females. Historically reported measles, mumps, rubella, varicella and vaccination for hepatitis B, influenza, measles, mumps and rubella are not associated with increased risk of MS later in life. A clinical history of infectious mononucleosis is conspicuously associated with increased MS susceptibility. These findings support studies implicating Epstein-Barr virus in MS disease susceptibility, but a co-association between MS susceptibility and clinically apparent infectious mononucleosis cannot be excluded.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Ramagopalan</LastName><ForeName>Sreeram V</ForeName><Initials>SV</Initials><AffiliationInfo><Affiliation>Wellcome Trust Centre for Human Genetics, Oxford, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Valdar</LastName><ForeName>William</ForeName><Initials>W</Initials></Author><Author ValidYN="Y"><LastName>Dyment</LastName><ForeName>David A</ForeName><Initials>DA</Initials></Author><Author ValidYN="Y"><LastName>DeLuca</LastName><ForeName>Gabriele C</ForeName><Initials>GC</Initials></Author><Author ValidYN="Y"><LastName>Yee</LastName><ForeName>Irene M</ForeName><Initials>IM</Initials></Author><Author ValidYN="Y"><LastName>Giovannoni</LastName><ForeName>Gavin</ForeName><Initials>G</Initials></Author><Author ValidYN="Y"><LastName>Ebers</LastName><ForeName>George C</ForeName><Initials>GC</Initials></Author><Author ValidYN="Y"><LastName>Sadovnick</LastName><ForeName>A Dessa</ForeName><Initials>AD</Initials></Author><Author ValidYN="Y"><CollectiveName>Canadian Collaborative Study Group</CollectiveName></Author></AuthorList><Language>eng</Language><GrantList CompleteYN="Y"><Grant><GrantID>G0801975</GrantID><Agency>Medical Research Council</Agency><Country>United Kingdom</Country></Grant></GrantList><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2009</Year><Month>02</Month><Day>11</Day></ArticleDate></Article><MedlineJournalInfo><Country>Switzerland</Country><MedlineTA>Neuroepidemiology</MedlineTA><NlmUniqueID>8218700</NlmUniqueID><ISSNLinking>0251-5350</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D019433">Chickenpox Vaccine</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D017325">Hepatitis B Vaccines</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D007252">Influenza Vaccines</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D008458">Measles Vaccine</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D009108">Mumps Vaccine</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D012411">Rubella Vaccine</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D002170" MajorTopicYN="N" Type="Geographic">Canada</DescriptorName><QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D016022" MajorTopicYN="N">Case-Control Studies</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D002644" MajorTopicYN="N">Chickenpox</DescriptorName><QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName><QualifierName UI="Q000517" MajorTopicYN="N">prevention & control</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D019433" MajorTopicYN="N">Chickenpox Vaccine</DescriptorName><QualifierName UI="Q000008" MajorTopicYN="N">administration & dosage</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D015331" MajorTopicYN="N">Cohort Studies</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D004198" MajorTopicYN="N">Disease Susceptibility</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D017325" MajorTopicYN="N">Hepatitis B Vaccines</DescriptorName><QualifierName UI="Q000008" MajorTopicYN="N">administration & dosage</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007244" MajorTopicYN="N">Infectious Mononucleosis</DescriptorName><QualifierName UI="Q000453" MajorTopicYN="Y">epidemiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D007252" MajorTopicYN="N">Influenza Vaccines</DescriptorName><QualifierName UI="Q000008" MajorTopicYN="N">administration & dosage</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008457" MajorTopicYN="N">Measles</DescriptorName><QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName><QualifierName UI="Q000517" MajorTopicYN="N">prevention & control</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008458" MajorTopicYN="N">Measles Vaccine</DescriptorName><QualifierName UI="Q000008" MajorTopicYN="N">administration & dosage</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D009103" MajorTopicYN="N">Multiple Sclerosis</DescriptorName><QualifierName UI="Q000453" MajorTopicYN="Y">epidemiology</QualifierName><QualifierName UI="Q000209" MajorTopicYN="N">etiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D009107" MajorTopicYN="N">Mumps</DescriptorName><QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName><QualifierName UI="Q000517" MajorTopicYN="N">prevention & control</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D009108" MajorTopicYN="N">Mumps Vaccine</DescriptorName><QualifierName UI="Q000008" MajorTopicYN="N">administration & dosage</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D012307" MajorTopicYN="N">Risk Factors</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D012409" MajorTopicYN="N">Rubella</DescriptorName><QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName><QualifierName UI="Q000517" MajorTopicYN="N">prevention & control</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D012411" MajorTopicYN="N">Rubella Vaccine</DescriptorName><QualifierName UI="Q000008" MajorTopicYN="N">administration & dosage</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D012737" MajorTopicYN="N">Sex Factors</DescriptorName></MeshHeading></MeshHeadingList><InvestigatorList><Investigator 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Deluca</name><name sortKey="Dyment, David A" sort="Dyment, David A" uniqKey="Dyment D" first="David A" last="Dyment">David A. Dyment</name><name sortKey="Ebers, George C" sort="Ebers, George C" uniqKey="Ebers G" first="George C" last="Ebers">George C. Ebers</name><name sortKey="Giovannoni, Gavin" sort="Giovannoni, Gavin" uniqKey="Giovannoni G" first="Gavin" last="Giovannoni">Gavin Giovannoni</name><name sortKey="Sadovnick, A Dessa" sort="Sadovnick, A Dessa" uniqKey="Sadovnick A" first="A Dessa" last="Sadovnick">A Dessa Sadovnick</name><name sortKey="Valdar, William" sort="Valdar, William" uniqKey="Valdar W" first="William" last="Valdar">William Valdar</name><name sortKey="Yee, Irene M" sort="Yee, Irene M" uniqKey="Yee I" first="Irene M" last="Yee">Irene M. Yee</name></noCountry><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Ramagopalan, Sreeram V" sort="Ramagopalan, Sreeram V" uniqKey="Ramagopalan S" first="Sreeram V" last="Ramagopalan">Sreeram V. 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